hCELA3A, His-Tag; inactive variant S217A


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SKU: P2020-129 trenzyme

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The elastase 3A is relative to pancreatic serine proteinases and has a low level of elastolytic activity comparing to other elastases. Elastase 3A is probably involved in the intestinal transport and metabolism of cholesterol. Furthermore, elastase 3A is an efficient protease that preferentially cleaves proteins after alanine residues due to its alanine specificity. Both elastase 3A and elastase 3B have been referred to as protease E and elastase 1. By substitution of the amino acid S217A the enzyme is rendered catalytically inactive.

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