hiMicroglia, assay-ready

Microglia are the resident immune cells of the central nervous system (CNS) and play essential roles in maintaining neuronal homeostasis, synaptic plasticity, normal brain development and immune surveillance. They are key mediators of inflammatory responses in the CNS and have been implicated in the pathogenesis of numerous neurological disorders, including Alzheimer´s disease, Parkinson´s disease and other neurodegenerative and neuroinflammatory conditions. 

Our hiMicroglia provide a robust, physiologically relevant in vitro model for studying their diverse functions. Generated from human iPSC using a optimized and highly standardized differentiation protocol, the cells closely resemble native human microglia by expressing the key marker IBA1, while exhibiting essential functional characteristics such as cytokine release and inflammatory responsiveness. 

The cryopreserved cells are fully differentiated and ready to use for your assay from Day 1. The cells recover efficiently after thawing (viability 85-90%), enabling consistent experimental performance while reducing hands-on time and batch-to-batch variability. 

In addition to monoculture studies, these hiMicroglia are ideally suited for co-culture CNS models to investigate neuroimmune crosstalk, synaptic remodeling and disease-relevant cellular interactions.

trenzyme has developed a production process for microglia from iPSC cells (human iPSC-derived). Please note: Microglia for research and development applications (RUO). Not for human or animal clinical trials, therapeutic or diagnostic use.