human APRIL, MBP/His-Tag


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SKU: P2020-167 trenzyme

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A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), plays a key role in promoting the survival, proliferation and differentiation of B cells, thereby contributing to the maintenance of humoral immunity. Moreover, APRIL induces class-switch recombination to immunoglobulin A (IgA), which is crucial for the generation of mucosal immunity and defense against pathogens at mucosal surfaces. Dysregulation of APRIL may result in excessive plasma cell activation and antibody production, leading to autoimmune pathology or the development of plasma cell malignancies, such as multiple myeloma. Thus, targeting APRIL has become an attractive therapeutic strategy.

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