Follistatin-related protein 3

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trenzyme SKU: P2020-128_100

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Size: 100µg

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Description

Follistatin-related protein 3 (FSTL3) is a secreted glycoprotein involved in a myriad of intracellular signaling pathways by binding to activin-A and myostatin, members of the TGF-ß family, thereby suppressing their cellular activity. Thus, FSTL3 plays a role in health and disease. Analysis of FSTL3 expression can serve as diagnostic biomarker and in-depth knowledge of its actions on intracellular signaling pathways will lead to the development of new therapeutic approaches.

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Overview
 Sequence Information Product Information Background Information Download
  • Product Name: Follistatin-related protein 3
  • Catalog No.: P2020-128
  • RefSeq Links: UniProt: O95633
  • Synonyms: Follistatin-like protein 3; Follistatin-related gene protein; FSTL3; FSRP; Follistatin-Related Protein; Follistatin Like 3; Follistatin-Like 3 (Secreted Glycoprotein); Follistatin-Related Protein 3
  • Species: Homo sapiens, human
  • Tags: His-Tag, C-terminal
  • Sequence without tags (AA 27-263):

    MGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGF
    LGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDEC
    ELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSP
    GQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV

  • Expression Host: human, HEK293
  • Formulation: PBS; pH 7.4.
  • Format: Liquid, stored and shipped at -80°C
  • Purity: > 80% as determined by SDS-PAGE

Human follistatin-related protein 3 (FSTL3) is a secrected glycoprotein, which is structurally and functionally related to the activin-binding protein follistatin. It is expressed in various organs and tissues such as placenta, testis, heart and lung and plays an important role in a variety of cellular functions. By binding to activin-A and myostatin, both members of the TGF-ß family, FSTL3 antagonizes their cellular activity, thereby regulating physiological processes including cell differentiation and proliferation, metabolic pathways, inflammation and tumor development.

SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture
SDS-PAGE of Follistatin-related protein 3
Histogram (of marked lane in gel picture) Follistatin-related protein 3

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