Price excl. shipping costs excl. VAT. For more information, see our shipping policy

SKU: P2020-112 trenzyme

Need a quote for an individual request or for a bulk order?

Please contact us.


Recombinant Alpha-1-antitrypsin or also known as Alpha-1-proteinase inhibitor is an inhibitor of serine proteases (Serpin). Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator.
The protein was produced using a mammalian cell system (HEK) and contains a His-Tag.


  • Product Name: Alpha-1-antitrypsin
  • Catalog No.: P2020-112
  • RefSeq Links: UniProt: P01009; NP_000286.3; NM_000295.4; PIR: A21853; GeneID: 5265
  • Synonyms: Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; A1AT Protein; Alfa1 antitrypsin; Alpha 1-antitrypsin; Alpha 1-Proteinase Inhibitor; Alpha 1-proteinase inhibitor (human); Alpha 1-proteinase inhibitor, human; Alpha-1 protease inhibitor; Alpha-1 proteinase inhibitor (human); Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha-1-proteinase Inhibitor (human); Alpha-1-proteinase inhibitor human; Alpha-1-proteinase Inhibitor, Human; Alpha-1-proteinase inhibitor, human; Alpha1-proteinase Inhibitor; Alpha1-proteinase inhibitor (human); alpha1-proteinase inhibitor human; API

Cellebrity Kolben Cell Cartoon trenzyme

Customer Testimonial

“We highly valued the fast and excellent communication and the high flexibility of the team! For any future project, we will preferably entrust in trenzyme’s protein production services.”

Dr. Thore Hettmann
Probiodrug AG, Halle/Saale, Germany

Sequence Information

  • Species: Homo sapiens
  • Tags: His-tag, N-terminal
  • Sequence without tags (AA 25-418):

Product Information

  • Expression Host: human, HEK293
  • Formulation: 10 mM Tris, 200 mM NaCl, 1 mM EDTA, 1 mM ß-Mercaptoethanol; pH 8.0
  • Format: Liquid, stored and shipped at -80°C
  • Purity: 95% as determined by SDS-PAGE

Background Information

Alpha-1-antitrypsin also known as Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) preventing the proteolysis of elastin tissues in alveolar lung structures. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.

SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture

SDS-Page Alpha-1-antitrypsin
Histogram Alpha-1-antitrypsin

Get in contact with us

By submitting this form, I consent to trenzyme GmbH receiving and processing my data in order to process my inquiry. My consent is voluntary and I may revoke this consent at any time without providing any reasons, e.g. by sending an email to privacy(at) with effect for the future. Further notices on data processing can be found in our privacy policy.