human Interleukin-1 beta, tag-free


Price excl. shipping costs excl. VAT. For more information, see our shipping policy

SKU: P2020-136 trenzyme

Need a quote for an individual request or for a bulk order?

Please contact us.


Interleukin-1 beta (IL-1 beta) is a pivotal pro-inflammatory cytokine mediating innate and adaptive immune responses in response to infection or cell injury. Moreover, IL-1 beta is involved in a variety of autoimmune and inflammatory diseases caused by enhanced secretion of the cytokine. In further consequence, chronic inflammatory conditions promote tumor development and cancer malignancy.


  • Product Name: human Interleukin-1 beta, tag-free
  • Catalog No.: P2020-136
  • RefSeq Links: NP_000567.1; NM_000576.2; pdb1tp0 UniProt: P01584
  • Synonyms: IL-1 beta; Catabolin; IL-1B, IL-1 beta Protein; IL1-BETA Protein; IL1F2 Protein
Cellebrity Kolben Cell Cartoon trenzyme

Customer Testimonial

“We highly valued the fast and excellent communication and the high flexibility of the team! For any future project, we will preferably entrust in trenzyme’s protein production services.”

Dr. Thore Hettmann
Probiodrug AG, Halle/Saale, Germany

Sequence Information

  • Species: Homo sapiens
  • Tags: Tag-free; His-tag removed by proteolytic digest
  • Sequence without tags (AA 117-269):


Product Information

  • Expression Host: E. coli
  • Formulation: PBS; pH 7.4
  • Format: Liquid, stored and shipped at -80° C
  • Purity: 95% as determined by SDS-PAGE

Background Information

The pro-inflammatory cytokine Interleukin-1 beta (IL-1 beta) is produced by a variety of cell types, including macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. Activation of IL-1 beta is tightly regulated as it is first produced as inactive precursor in response to infection or cell injury and has to be proteolytically cleaved by caspase-1, which is activated by a cytosolic pro-inflammatory signaling complex, the inflammasome. Proteolytic cleavage of pro-IL-1 beta results in secretion of mature IL-1 beta and induction of inflammatory responses by binding to the IL-1 type I receptor (IL-1RI). In particular, activation of IL-1 beta induces inflammation, fever, synthesis of acute phase proteins, as well as proliferation and differentiation of lymphocytes emphasizing its versatile biological functions. Activity is further regulated by several endogenous inhibitors including IL-1 type II receptor (IL-1RII) and IL-1 receptor antagonist (IL-1Ra). Dysregulation causes pathological conditions ranging from chronic inflammatory and autoinflammatory diseases to autoimmune syndromes, neurodegenerative diseases and cancer.


SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture

human Interleukin-1 beta tag-free sds page
human Interleukin-1 beta tag-free histogram densitometry

Get in contact with us

By submitting this form, I consent to trenzyme GmbH receiving and processing my data in order to process my inquiry. My consent is voluntary and I may revoke this consent at any time without providing any reasons, e.g. by sending an email to privacy(at) with effect for the future. Further notices on data processing can be found in our privacy policy.