![Structural model of SARS-CoV-2 S1 (RBD) Gamma, P.1 (Brazil), GFP/His-Tag](http://shop.trenzyme.com/cdn/shop/products/NEW_s1-protein_mutation_structural-model_K417T-E484K-N501Y_{width}x.png?v=1634740954)
SARS-CoV-2 S1 (RBD) Gamma, P.1 (Brazil), GFP/His-Tag
€420.00 €470.00
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SKU: P2020-043 trenzyme
Description
Recombinant protein of the receptor binding domain (RBD), Mutant (K417T-E484K-N501Y) of SARS-CoV-2 (COVID-19) Spike S1 from Wuhan pneumonia virus with C-terminal His/GFP-Tag. The mutations K417T-E484K-N501Y are characteristic for the fast spreading SARS-CoV-2 virus Gamma variant (P.1 lineage) emerged in Brazil. These mutations are affecting the receptor binding domain (RBD) of the spike protein, which the virus uses to bind to human cells receptors and enter them. Due to the mutations, the virus is allowed to bind with higher affinity to human ACE2 receptor, which results in approximately 160% increased transmissibility of the SARS-CoV-2 virus Gamma variant.
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