hGuanylatekinase, His-Tag

• Product Name: hGuanylatekinase, His-Tag
  
• Catalog No.: P2020-107
• RefSeq Links: UniProt: Q16774
• Synonyms: guanosine monophosphate kinase; GMK; GMPK; Guanylate kinase; GUK1; hGMPK; human Guanylate kinase; GMP Kinase

• Species: Homo sapiens, human
• Tags: His-Tag, N-terminal
• Sequence without tags (AA 1-198):
  MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
  SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
  LKEALSEEIKKAQRTGA

• Expression Host: human, HEK293
• Formulation: PBS, pH 7,4
• Format: Liquid, stored and shipped at -80°C
• Purity: > 95% as determined by SDS-PAGE

Human Guanylate kinase is the only known enzyme which catalyzes the ATP-dependent phosphorylation of cellular guanosine monophosphate (GMP) into guanosine diphosphate (GDP). Process is crucial for GMP and cyclic guanosine monophosphate (cGMP) recycling, essential for cellular viability and proliferation. It occurs in low eukaryotes, prokaryotes as well as in vertebrates. Human Guanylate kinase is a monomeric protein that is highly conserved and made up of approximately 200 amino acids. This enzyme belongs to the family of transferases with a phosphate group as phosphotransferases. The hGuanylatekinase is essential for producing the nucleotide building blocks of DNA, RNA. That enzyme is indispendable in metabolic activation of antiviral prodrugs. The hGuanylatekinase structure consists of three particular domains that are dynamic: LID, GMP-binding, and CORE domain.

SDS-PAGE/Coll. Coomassie	Histogram of marked lane in gel picture

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