human B7-1/CD80, MBP/His-Tag

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trenzyme SKU: P2020-162_100

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Size: 100µg

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Description

B7-1, also known as cluster of differentiation 80 (CD80), is a cell surface glycoprotein expressed on antigen-presenting cells (APCs) and plays a crucial role in regulating adaptive immune responses. As co-stimulatory molecule, B7-1 binds to CD28 expressed on the surface of T cells and thereby, provides a second signal that is inevitable for T cell activation, proliferation and differentiation into effector and memory T cells. Inhibitory signals induced by interaction of B7-1 with the cytotoxic T lymphocyte antigen-4 (CTLA-4) limit initial T cell activation in secondary lymphoid organs in order to prevent excessive immune stimulation. Modulating the B7-1/CD28 and B7-1/CTLA-4 interactions can have significant effects on immune responses and thus, represents a promising strategy to treat various autoimmune diseases and cancer.

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Overview
 Sequence Information Product Information Background Information Download
  • Product Name: human B7-1/CD80, MBP/His-Tag
  • Catalog No.: P2020-162
  • RefSeq Links: HGNC:1700; NX_P33681; NM_005191.4; NP_005182.1; PDBe 1dr9; UniProt: P33681
  • Synonyms: T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1 (B7), B7-1, CD28LG, CD28LG1, LAB7
  • Species: Homo sapiens
  • Tags: MBP/His-tag, N-terminal
  • Sequence without tags (AA 35-242):
    MVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFD
    ITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPT
    SNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSF
    MCLIKYGHLRVNQTFNWNTTKQEHFPDN
  • Expression Host: HEK293
  • Formulation: PBS; pH 7.4
  • Format: Liquid, stored and shipped at -80° C
  • Purity: > 95 % as determined by SDS-PAGE
  • Application: ELISA, WB, Functional assay

The cell surface glycoprotein B7-1, also known as cluster of differentiation 80 (CD80), belongs to the B7 family of co-stimulatory molecules, which are expressed on antigen-presenting cells (APCs), including dendritic cells, macrophages and B cells. Resting APCs express low levels of B7 molecules, but various stimuli, such as microbial products and cytokines produced during innate immune reactions against pathogens, induce an increased expression of B7 molecules in order to promote adaptive immune responses. This regulated expression ensures that T cells are activated only when needed. When T cells encounter antigens displayed by APCs, which is the first signal required for complete T cell activation, B7-1 interacts with CD28 providing a co-stimulatory signal, the second crucial signal. B7-1 has a higher affinity for CD28 than B7-2, which may influence the strength and duration of co-stimulatory signals during T cell activation. T cell activation leads to cytokine production and proliferation of T cells as well as differentiation into effector and memory T cells. This interaction is counterbalanced by the cytotoxic T lymphocyte antigen-4 (CTLA-4), which is expressed on T cells after antigen recognition and has a higher affinity for B7-1 than CD28. CTLA-4 provides inhibitory signals leading to downregulation of immune responses. Dysregulation of B7-1 causes autoimmune diseases, inflammatory disorders and cancer. Therefore, therapeutic strategies targeting B7-1 or its interactions are being explored to dampen autoimmune diseases and to enhance anti-cancer immunity.


SDS-PAGE/Coll. Coomassie

Histogram of marked lane in gel picture
SDS-Page of human B7-1/CD80, MBP/His-Tag
Histogram of human B7-1/CD80, MBP/His-Tag

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