human CTLA-4


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SKU: P2020-149 trenzyme

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a crucial immune checkpoint receptor that functions as negative regulator of T cell activation in order to prevent excessive immune responses and maintain immune homeostasis. Dysregulation of CTLA-4 results in various autoimmune diseases and cancers. Therefore, several therapeutic strategies targeting CTLA-4, such as CTLA-4-immunoglobulin fusion proteins and immune checkpoint inhibitors, have been developed to control autoimmune responses by inhibiting T cell activation and to enhance anti-tumor immune responses, respectively.

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