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SKU: P2020-161 trenzyme

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Legumain, also known as asparaginyl endopeptidase (AEP), is a lysosomal cysteine protease that specifically hydrolyzes peptide bonds after asparagine residues, playing a crucial role in various physiological and pathological processes. It contributes to protein turnover and recycling as it is involved in the degradation of proteins within lysosomes. Moreover, it participates in the generation of antigenic peptides for major histocompatibility complex (MHC) class II presentation, thereby contributing to the activation of T lymphocytes. Dysregulation of legumain promotes neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, and is associated with autoimmune diseases, chronic inflammation and various cancer types. Therefore, legumain represents a promising therapeutic target and serves as a potential diagnostic biomarker.

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